Kort om
Professor Niclas Karlssons forskning fokuserer på rollen til glykosylering i menneskers helse. Glykaner er allestedsnærværende i biologiske grensesnitt, inkludert glykokalyx på cellemembraner, på slimhinneoverflater som beskytter mage-tarm-, lunge- og reproduktive kanaler og leddene i muskelskjelettsystemet. Gruppen bruker state-of-the-art massespektrometrisk og HPLC-basert glykomikk og glykoproteomikk av både N-linked og O-linked glykoproteiner for å identifisere patologisk endring av glykosyleringen.
Databaser:
UniCarb-DB (https://unicarb-db.expasy.org)
UniCarb-DR (https://unicarb-dr.glycosmos.org).
Publikationer:
Pubmed (https://www.ncbi.nlm.nih.gov/myncbi/1-Wzd4_y7_JkD/bibliography/public/)
Twitter: UniCarb-DB@NG_Karlsson
Forskningsgrupper
Publikasjoner og forskningsresultater
Vitenskapelige publikasjoner
Urban, James; Jin, Chunsheng; Thomsson, Kristina A.;
Karlsson, Niclas
; Ives, Callum M.; Fadda, Elisa; Bojar, Daniel
(2024).
Predicting glycan structure from tandem mass spectrometry via deep learning.
9 s.
Nature Methods.
Vol. 21.
https://doi.org/10.1038/s41592-024-02314-6
Jin, Chunsheng; Venkatakrishnan, Vignesh; Thomsson, Kristina A.; Aoki, Nobuyuki P.; Shinmachi, Daisuke; Aoki-Kinoshita, Kiyoko F.; Hayes, Catherine A.; Lisacek, Frédérique;
Karlsson, Niclas
(2024).
UniCarb-DB: An MS/MS Experimental Glycomic Fragmentation Database.
19 s.
Methods in molecular biology.
Vol. 2836.
https://doi.org/10.1007/978-1-0716-4007-4_6
Swisa, Avital; Kieckhaefer, Julia; Daniel, Scott G.; El-Mekkoussi, Hilana; Kolev, Hannah M.; Tigue, Mark; Jin, Chunsheng; Assenmacher, Charles-Antoine; Dohnalová, Lenka; Thaiss, Christoph A.;
Karlsson, Niclas
; Bittinger, Kyle; Kaestner, Klaus H.
(2024).
The evolutionarily ancient FOXA transcription factors shape the murine gut microbiome via control of epithelial glycosylation.
Developmental Cell.
https://doi.org/10.1016/j.devcel.2024.05.006
Saldova, Radka; Thomsson, Kristina A.; Wilkinson, Hayden; Chatterjee, Maitrayee; Singh, Ashish K.;
Karlsson, Niclas
; Knaus, Ulla G.
(2024).
Characterization of intestinal O-glycome in reactive oxygen species deficiency.
PLOS ONE.
Vol. 19.
https://doi.org/10.1371/journal.pone.0297292
Bechtella, Leïla; Chunsheng, Jin; Fentker, Kerstin; Ertürk, Güney R.; Safferthal, Marc; Polewski, Łukasz; Götze, Michael; Graeber, Simon Y.; Vos, Gaël M.; Struwe, Weston B.; Mall, Marcus A.; Mertins, Philipp;
Karlsson, Niclas
; Pagel, Kevin
(2024).
Ion mobility-tandem mass spectrometry of mucin-type O-glycans.
Nature Communications.
Vol. 15.
https://doi.org/10.1038/s41467-024-46825-4
Acharya, Binayak;
Tofthagen, Marthe
;
Maciej-Hulme, Marissa Lucy
; Suissa, Michal Rachel;
Karlsson, Niclas
(2024).
Limited support for a direct connection between prebiotics and intestinal permeability – a systematic review.
Glycoconjugate Journal.
https://doi.org/10.1007/s10719-024-10165-8
Rustad, Cecilie F.; Backe, Paul Hoff; Jin, Chunsheng; Merckoll, Else; Tveten, Kristian;
Maciej-Hulme, Marissa Lucy
;
Karlsson, Niclas
; Prescott, Trine; Mørk Sandås, Elise; Woldseth, Berit; Elgstøen, Katja B. Prestø; Holla, Øystein Lunde
(2024).
A monoallelic UXS1 variant associated with short-limbed short stature.
Molecular Genetics & Genomic Medicine.
Vol. 12.
https://doi.org/10.1002/mgg3.2472
Elsaid, Khaled; Merriman, Tony R.; Rossitto, Leigh-Ana; Liu-Bryan, Ru; Karsh, Jacob; Phipps-Green, Amanda; Jay, Gregory D.; Elsayed, Sandy; Qadri, Marwa; Miner, Marin; Cadzow, Murray; Dambruoso, Talia J.; Schmidt, Tannin A.; Dalbeth, Nicola; Chhana, Ashika; Höglund, Jennifer; Ghassemian, Majid; Campeau, Anaamika; Maltez, Nancy;
Karlsson, Niclas
; Gonzalez, David J.; Terkeltaub, Robert
(2023).
Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia.
Arthritis & Rheumatology.
Vol. 75.
https://doi.org/10.1002/art.42413
De Marco Verissimo, Carolina; Cwiklinski, Krystyna; Nilsson, Jonas; Mirgorodskaya, Ekaterina; Jin, Chunsheng;
Karlsson, Niclas
; Dalton, John P.
(2023).
Glycan Complexity and Heterogeneity of Glycoproteins in Somatic Extracts and Secretome of the Infective Stage of the Helminth Fasciola hepatica.
Molecular & Cellular Proteomics.
Vol. 22.
https://doi.org/10.1016/j.mcpro.2023.100684
Andersson, Elin; Tykesson, Emil; Lohmander, L. Stefan;
Karlsson, Niclas
; Jin, Chunsheng; Mirgorodskaya, Ekaterina; Swärd, Per; Struglics, André
(2023).
Quantification of chondroitin sulfate, hyaluronic acid and N-glycans in synovial fluid – A technical performance study.
Osteoarthritis and Cartilage Open.
Vol. 5.
https://doi.org/10.1016/j.ocarto.2023.100380
