Fagområder
Vitenskapsdisipliner
Nevrologi Medisinsk immunologi Medisinsk genetikk Molekylærbiologi Matematikk og naturvitenskap
Emner
Genregulering Multippel sklerose Vitamin D Autoimmunitet T celler
Forskningsprosjekter
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Identifisering av epigenetiske biomarkører for medikamentrespons hos pasienter med multippel sklerose
Prosjektet "epiNOR-MS" er et trinn på veien mot persontilpasset medisin.
Publikasjoner og forskningsresultater
Vitenskapelige publikasjoner
Kennedy, Keith E.; de Rosbo, Nicole Kerlero; Uccelli, Antonio; Cellerino, Maria; Ivaldi, Federico; Contini, Paola; De Palma, Raffaele; Harbo, Hanne-Cathrin Flinstad;
Berge, Tone
; Bos, Steffan Daniel; Høgestøl, Einar August; Brune-Ingebretsen, Synne; de Rodez Benavent, Sigrid Aune; Paul, Friedemann; Brandt, Alexander U.; Bäcker-Koduah, Priscilla; Behrens, Janina; Kuchling, Joseph; Asseyer, Susanna; Scheel, Michael; Chien, Claudia; Zimmermann, Hanna; Motamedi, Seyedamirhosein; Kauer-Bonin, Josef; Saez-Rodriguez, Julio; Rinas, Melanie; Alexopoulos, Leonidas G.; Andorra, Magi; Llufriu, Sara; Saiz, Albert; Blanco, Yolanda; Martinez-Heras, Eloy; Solana, Elisabeth; Pulido-Valdeolivas, Irene; Martinez-Lapiscina, Elena H.; Garcia-Ojalvo, Jordi; Villoslada, Pablo
(2024).
Multiscale networks in multiple sclerosis.
PLoS Computational Biology.
Vol. 20.
https://doi.org/10.1371/journal.pcbi.1010980
Andorra, Magi; Freire, Ana; Zubizarreta, Irati; de Rosbo, Nicole Kerlero; Bos, Steffan Daniel; Rinas, Melanie; Høgestøl, Einar August; de Rodez Benavent, Sigrid Aune;
Berge, Tone
; Brune, Synne; Ivaldi, Federico; Cellerino, Maria; Pardini, Matteo; Vila, Gemma; Pulido-Valdeolivas, Irene; Martinez-Lapiscina, Elena H.; Llufriu, Sara; Saiz, Albert; Blanco, Yolanda; Martinez-Heras, Eloy; Solana, Elisabeth; Bäcker-Koduah, Priscilla; Behrens, Janina; Kuchling, Joseph; Asseyer, Susanna; Scheel, Michael; Chien, Claudia; Zimmermann, Hanna; Motamedi, Seyedamirhosein; Kauer-Bonin, Josef; Brandt, Alex; Saez-Rodriguez, Julio; Alexopoulos, Leonidas G.; Paul, Friedemann; Harbo, Hanne-Cathrin Flinstad; Shams, Hengameh; Oksenberg, Jorge; Uccelli, Antonio; Baeza-Yates, Ricardo; Villoslada, Pablo
(2023).
Predicting disease severity in multiple sclerosis using multimodal data and machine learning.
17 s.
Journal of Neurology.
https://doi.org/10.1007/s00415-023-12132-z
Brune-Ingebretsen, Synne; Høgestøl, Einar August; de Rosbo, Nicole Kerlero; Berg-Hansen, Pål; Brunborg, Cathrine; Blennow, Kaj; Zetterberg, Henrik; Paul, Friedemann; Uccelli, Antonio; Villoslada, Pablo; Harbo, Hanne-Cathrin Flinstad;
Berge, Tone
(2023).
Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis.
11 s.
Journal of Neuroimmunology.
Vol. 382.
https://doi.org/10.1016/j.jneuroim.2023.578175
Harroud, Adil; Stridh, Pernilla; McCauley, Jacob L.; Saarela, Janna Saija; van den Bosch, Aletta M. R.; Engelenburg, Hendrik J.; Beecham, Ashley H.; Alfredsson, Lars; Alikhani, Katayoun; Amezcua, Lilyana; Andlauer, Till F. M.; Ban, Maria; Barcellos, Lisa F.; Barizzone, Nadia;
Berge, Tone
; Berthele, Achim; Bittner, Stefan; Bos, Steffan Daniel; Briggs, Farren B. S.; Caillier, Stacy J.; Calabresi, Peter A.; Caputo, Domenico; Carmona-Burgos, David X.; Cavalla, Paola; Celius, Elisabeth Gulowsen; Cerono, Gabriel; Chinea, Angel R.; Chitnis, Tanuja; Clarelli, Ferdinando; Comabella, Manuel; Comi, Giancarlo; Cotsapas, Chris; Cree, Bruce C. A.; D’Alfonso, Sandra; Dardiotis, Efthimios; De Jager, Philip L.; Delgado, Silvia R.; Dubois, Bénédicte; Engel, Sinah; Esposito, Federica; Fabis-Pedrini, Marzena J.; Filippi, Massimo; Fitzgerald, Kathryn C.; Gasperi, Christiane; Gomez, Lissette; Gomez, Refujia; Hadjigeorgiou, Georgios; Hamann, Jörg; Held, Friederike; Henry, Roland G.; Hillert, Jan; Huang, Jesse; Huitinga, Inge; Islam, Talat; Isobe, Noriko; Jagodic, Maja; Kermode, Allan G.; Khalil, Michael; Kilpatrick, Trevor J.; Konidari, Ioanna; Kreft, Karim L.; Lechner-Scott, Jeannette; Leone, Maurizio; Luessi, Felix; Malhotra, Sunny; Manouchehrinia, Ali; Manrique, Clara P.; Martinelli-Boneschi, Filippo; Martinez, Andrea C.; Martinez-Maldonado, Viviana; Mascia, Elisabetta; Metz, Luanne M.; Midaglia, Luciana; Montalban, Xavier; Oksenberg, Jorge R.; Olsson, Tomas; Oturai, Annette; Pääkkönen, Kimmo; Parnell, Grant P.; Patsopoulos, Nikolaos A.; Pericak-Vance, Margaret A.; Piehl, Fredrik; Rubio, Justin P.; Santaniello, Adam; Santoro, Silvia; Schaefer, Catherine; Sellebjerg, Finn; Shams, Hengameh; Shchetynsky, Klementy; Silva, Claudia; Siokas, Vasileios; Søndergaard, Helle B.; Sorosina, Melissa; Taylor, Bruce; Vandebergh, Marijne; Vasileiou, Elena S.; Vecchio, Domizia; Voortman, Margarete M.; Weiner, Howard L.; Wever, Dennis; Yong, V. Wee; Hafler, David A.; Stewart, Graeme J.; Compston, Alastair; Zipp, Frauke; Harbo, Hanne-Cathrin Flinstad; Hemmer, Bernhard; Goris, An; Smolders, Joost; Hauser, Stephen L.; Kockum, Ingrid; Sawcer, Stephen; Baranzini, Sergio E.; Jónsdóttir, Ingileif; Blanco, Yolanda; Llufriu, Sara; Madireddy, Lohith; Saiz, Albert; Villoslada, Pablo; Stefánsson, Kári
(2023).
Locus for severity implicates CNS resilience in progression of multiple sclerosis.
Nature.
Vol. 619.
https://doi.org/10.1038/s41586-023-06250-x
Brune, Synne; Høgestøl, Einar August; de Rodez Benavent, Sigrid Aune; Berg-Hansen, Pål;
Beyer, Mona K.
; Leikfoss, Ingvild Sørum; Bos, Steffan Daniel; Sowa, Piotr; Brunborg, Cathrine; Andorra, Magi; Pulido Valdeolivas, Irene; Asseyer, Susanna; Brandt, Alexander; Chien, Claudia; Scheel, Michael; Blennow, Kaj; Zetterberg, Henrik; Kerlero de Rosbo, Nicole; Paul, Friedemann; Uccelli, Antonio; Villoslada, Pablo;
Berge, Tone
; Harbo, Hanne-Cathrin Flinstad
(2022).
Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis.
Multiple Sclerosis.
Vol. 28.
https://doi.org/10.1177/13524585221097296
Rise, Henning Hoel; Brune, Synne; Chien, Claudia;
Berge, Tone
; Bos, Steffan Daniel; Andorrà, Magí; Valdeolivas, Irene Pulido;
Beyer, Mona K.
; Sowa, Piotr; Scheel, Michael; Brandt, Alexander U.; Asseyer, Susanna; Blennow, Kaj; Pedersen, Mads Lund; Zetterberg, Henrik; de Schotten, Michel Thiebaut; Cellerino, Maria; Uccelli, Antonio; Paul, Friedemann; Villoslada, Pablo; Harbo, Hanne-Cathrin Flinstad; Westlye, Lars Tjelta; Høgestøl, Einar August
(2022).
Brain disconnectome mapping derived from white matter lesions and serum neurofilament light levels in multiple sclerosis: A longitudinal multicenter study.
NeuroImage: Clinical.
Vol. 35.
https://doi.org/10.1016/j.nicl.2022.103099
Cappelletti, Chiara; Eriksson, Anna Maria; Brorson, Ina Skaara; Leikfoss, Ingvild Sørum; Glomstad Kråbøl, Oda; Høgestøl, Einar August; Vitelli, Valeria; Mjaavatten, Olav; Harbo, Hanne-Cathrin Flinstad; Berven, Frode Steingrimsen; Bos-Haugen, Steffan Daniel;
Berge, Tone
(2022).
Quantitative proteomics reveals protein dysregulation during T cell activation in multiple sclerosis patients compared to healthy controls.
Clinical Proteomics.
Vol. 19.
https://doi.org/10.1186/s12014-022-09361-1
Brorson, Ina Skaara; Eriksson, Anna Maria; Høgestøl, Einar August; Leikfoss, Ingvild Sørum; Harbo, Hanne-Cathrin Flinstad;
Berge, Tone
; Vitelli, Valeria; Bos, Steffan Daniel
(2022).
Global DNA methylation changes in treated and untreated MS patients measured over time.
8 s.
Journal of Neuroimmunology.
Vol. 364.
https://doi.org/10.1016/j.jneuroim.2022.577808
König, Marton; Lorentzen, Åslaug Rudjord; Torgauten, Hilde Marie; Tran, Trung; Schikora-Rustad, Stine; Vaage, Eline Benno; Mygland, Åse Daasvand; Wergeland, Stig; Aarseth, Jan Harald; Aaberge, Ingeborg Sundsvalen; Torkildsen, Øivind; Holmøy, Trygve;
Berge, Tone
; Myhr, Kjell-Morten; Harbo, Hanne-Cathrin Flinstad; Andersen, Jan Terje; Munthe, Ludvig Andre; Søraas, Arne Vasli; Celius, Elisabeth Gulowsen; Vaage, John T.; Lund-Johansen, Fridtjof; Nygaard, Gro Owren
(2021).
Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations.
4 s.
Journal of Neurology, Neurosurgery and Psychiatry.
https://doi.org/10.1136/jnnp-2021-327612
Aamodt, Anne Hege; Høgestøl, Einar August; Popperud, Trine Haug; Holter, Jan Cato; Dyrhol-Riise, Anne Ma; Tonby, Kristian; Stiksrud, Birgitte; Paulsen, Else Quist;
Berge, Tone
; Barratt-Due, Andreas; Aukrust, Pål; Heggelund, Lars; Blennow, Kaj; Zetterberg, Henrik; Harbo, Hanne Flinstad
(2021).
Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19.
Journal of Neurology.
https://doi.org/10.1007/s00415-021-10517-6