!
Arrangementet har utgått!

Dette arrangementet har utgått og vil bli fjernet fra våre nettsider 30 dager etter arrangementsdato.

Disputas: Gia Deyab

Gia Deyab will defend her thesis for the PhD in Health Sciences.

Gia Deyab will defend her thesis “Effect of antirheumatic treatment on endothelial function and levels of pentraxin 3 and selenium in patients with inflammatory arthritis” for the PhD in Health Sciences.

Trial Lecture

August 16 2019 at 10:00

Title: Major determinants of thromboembolic risk in RA: relevance for targeted therapies.

Public defense

The candidate will defend her thesis August 16 at 12:15

We ask the audience to take their seats in good time before the public defense commences.

Ordinary opponents

Leader of the public defence

Associate Professor Jonas Debesay, Oslo Metropolitan University

Supervisors

  • Abstract

    In order to improve treatment of atherosclerosis and its accelerated form in inflammatory arthritis (IA), as well as of IA themselves, it is essential to improve insights into pathophysiology of these conditions, and to find optimal biomarkers for monitoring IA activity and cardiovascular (CV) risk. 

    Therefore, we focused on three parameters suspected to be involved in pathophysiology of CV disease (CVD) and/or inflammation: endothelial function (EF), pentraxin 3 (PTX3) and selenium levels.  Impaired EF, one of the first steps of atherosclerosis, is a valuable biomarker of CV risk. PTX3, an important molecule of the innate immune system, has been proposed to be a useful biomarker of both inflammation and CV risk due to its production in the inflamed tissue and fast response. Selenium deficit appears to enhance CVD risk and inflammation. We examined patients from PSARA, a prospective longitudinal observational study comprising 140 patients with rheumatoid arthritis, psoriasis arthritis or ankylosing spondylitis starting with methotrexate and/or anti-TNF therapy due to active disease.  We assessed the patients at baseline and after 6 weeks and 6 months of treatment. In IA patients with endothelial dysfunction, EF rapidly improved with antirheumatic treatment, independent of change in inflammatory status. Hence, besides the anti-inflammatory effects, also other modes of actions of disease modifying antirheumatic drugs may contribute to their atheroprotective effects. The IA patients had increased PTX3 levels that, in contrast to other inflammatory factors, did not change with treatment. Hence, the high PTX3 levels in IA might reflect an ongoing immune process not modifiable by the given antirheumatic treatment. Selenium levels (72µg/L) were within reference range but below the limit of 80-85 µg/L that is considered optimal for CVD protection. Thus, further research is necessary to clarify if selenium insufficiency contributes to increased CV risk in IA, or if the previously observed link between selenium levels and CV risk is caused by underlying inflammation. Intriguingly, selenium levels increased with treatment, potentially due to inhibition of selenium consuming proinflammatory processes.

    Taken together, our results can contribute to better insights into the pathogenesis in IA and the associated accelerated CVD, and in pharmacological actions of two of the most common antirheumatic regimens, and consequently facilitate development of better management strategies for these conditions.